Vitamin B12 - 500

For treatment of megaloblastic anemia; for prophylaxis and treatment of Vitamin B12 deficiency (macrocytic and megaloblastic anemia, incomplete nutrition and intestinal malabsorption, post gastric resection state and surgical removal of glands). As additional therapy in the treatment of: chronic alcoholism; fish tapeworm disease; in chronic atrophic gastritis; in genetic diseases (homocystinuria, methylmalonic aciduria); chronic hepatic diseases – hepatic steatosis, hepatitis, cirrhosis, etc.; hyperthyroidism; chronic enterocolitis with steatorrhea, tropical sprue, regional enteritis, persistent diarrhea, after ileum resection; neurasthenia (fatigue syndrome); diseases of the peripheral nervous system (neuritis, radiculitis, plexitis, etc.).

It is applied intramuscularly.

Adults: in megaloblastic anemia 500 to 1000 mcg daily for 10 to 12 days, maintenance dose of 250 mcg once per month during the first 3-6 months, then 250 mcg every 2-3 months.

In hepatic diseases, Vitamin B12 is applied every other day at a maximum daily dose of 500 mcg in a therapeutic course of 20 applications.

In mild vitamin B12 deficiency states, 100 mcg (0.1 mg) daily during the first week, followed by 100 mcg (0.1 mg) every other day during the second and third weeks, then the same dose every 3-4 days for the next 2-3 weeks. The treatment with these doses continues until clinical remission is obtained.

As maintenance therapy, it is applied intramuscularly at a dose of 100 to 200 mcg (0.1 to 0.2 mg) once per month.

In children, it is applied intramuscularly at a dose of 30-50 mcg (0.03-0.05 mg) daily over a period of 2 or more weeks (the total dose ranges from 1 to 5 mg).

For maintenance treatment: intramuscularly 100 mcg (0.1 mg) once per month.